目的:探讨缩宫素受体拮抗剂阿托西班在囊胚解冻移植中的作用。方法:回顾性分析264例行冻融囊胚移植患者的临床资料,移植前行单剂量阿托西班(6.75 mg/0.9 ml,iv)预处理者为研究组(n=117),移植前未使用阿托西班预处理者为对照组(n=147)。结果:研究组的胚胎着床率(53.1%)明显高于对照组(40.1%),差异有统计学意义(P=0.003);研究组临床妊娠率(66.7%)亦明显高于对照组(55.4%),差异有统计学意义(P=0.041)。结论:囊胚解冻移植前给予阿托西班预处理可明显改善患者的妊娠结局。 Objective: To investigate the role of atosiban, an oxytocin receptor antagonist, in thawed blastocysts. Methods: The clinical data of 264 patients with frozen-thawed blastocyst transplantation were retrospectively analyzed. Before the transplantation, a single dose of atosiban (6.75 mg / 0.9 ml, iv) was used as the study group (n = 117) Atorixib preconditioners were not used as controls (n = 147). Results: The embryo implantation rate (53.1%) in the study group was significantly higher than that in the control group (40.1%) (P = 0.003). The clinical pregnancy rate (66.7%) in the study group was also significantly higher than that in the control group 55.4%), the difference was statistically significant (P = 0.041). Conclusion: Pretreatment with Atosiban before thawing of blastocysts can significantly improve the pregnancy outcome.