A series of novel and convenient fluorescent probes with Schiff base functionality were presented for direct detection of OCl~- via the irreversible OCl~- -promoted oxidation and hydrolyzation reaction in formation of the ring-opened product, fluorescein. Prominent high sensitivity, selectivity and antiinterference OCl~- induced fluorescence and color change over a wide range of tested metal ions performance were observed for each probe under physiological conditions, thus making the probes well suitable for sensing of OCl~- in living cells. A series of novel and convenient fluorescent probes with Schiff base functionality were presented for direct detection of OCl ~ - via the irreversible OCl ~ - -promoted oxidation and hydrolyzation reaction in formation of the ring-opened product, fluorescein. Prominent high sensitivity, selectivity and antiinterference OCl ~ - induced fluorescence and color change over a wide range of tested metal ions performance were observed for each probe under physiological conditions, thus making the probes well suitable for sensing of OCl ~ - in living cells.