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目的探讨EV71、COX16、白细胞计数和C-反应蛋白联合检测在手足口病早期诊断中的应用。方法选取2015年1月~2016年7月云浮市妇幼保健院内儿科和儿科门诊就诊的1170例疑似手足口病患儿,分别检测白细胞计数(WBC)、C-反应蛋白(hs-CRP)、肠道病毒71型(EV71)、柯萨奇病毒A16型(COX16)。结果用血清学检测结果表明,COX16检测阳性为115例,阳性率为9.8%,EV71检测阳性为139例,阳性率为11.9%;柯萨奇病毒A16型联合肠道病毒71型检测同时阳性的患儿为93例,阳性率为7.9%;柯萨奇病毒A16型联合肠道病毒71型检测任意一项阳性为347例,阳性率为29.7%。结论 EV71、COX16、白细胞计数和C-反应蛋白联合检测操作简单、快速,是手足口病早期诊断中的敏感而非特异性指标,对临床诊疗、监测病情及判断预后有一定的意义。
Objective To investigate the application of EV71, COX16, leukocyte count and C-reactive protein in the early diagnosis of hand-foot-mouth disease. Methods From January 2015 to July 2016, 1170 children with suspected HFMD in pediatrics and pediatrics outpatient department of Yunfu MCH hospital were enrolled and their WBC, C-reactive protein (hs-CRP) Road virus 71 (EV71), Coxsackie virus A16 (COX16). Results The results of serological tests showed that the positive rate of COX16 was 115, the positive rate was 9.8%, the positive rate of EV71 was 139 and the positive rate was 11.9%. Coxsackie A16 and enterovirus 71 were positive There were 93 cases of children with positive rate of 7.9%. Coxsackie A16 and enterovirus 71 were positive in 347 cases, the positive rate was 29.7%. Conclusions The combined detection of EV71, COX16, WBC and C-reactive protein is simple and rapid. It is a sensitive and non-specific index for the early diagnosis of HFMD. It has certain significance for clinical diagnosis, monitoring of disease and prognosis.