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目的:制备芹黄素纳米脂质载体制剂并进行质量评价。方法:采用高温乳化-低温固化法制备芹黄素纳米脂质载体制剂,并对其形态、粒径、表面电位、包封率、载药量、体外释药等特性进行考察。结果:得到的芹黄素纳米粒为类球形,粒径分布均匀,平均粒径为212.1 nm,Zeta电位为-14.65 mV,平均包封率为82.4%,平均载药量为0.97%,体外2 h累积释药30%,随后释药过程趋于缓慢。结论:所制备的芹黄素纳米脂质载体制剂性质稳定,有良好的应用前景。
Objective: To prepare and evaluate the quality of the formulation of apigenin nano-lipid carrier. Methods: The preparation of apigenin nanoliposomes was prepared by high temperature emulsification-low temperature curing method. The morphology, particle size, surface potential, entrapment efficiency, drug loading and in vitro drug release were investigated. Results: The obtained nanoparticles were spherical in shape with uniform particle size distribution. The average particle size was 212.1 nm, the Zeta potential was -14.65 mV, the average entrapment efficiency was 82.4% and the average drug loading was 0.97% h cumulative release of 30%, followed by drug release process tends to be slow. Conclusion: The preparation of apigenin nano-lipid carrier preparation is stable in nature and has good application prospects.