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在使用ATRA治疗前,中枢神经系统(CNS)复发在APL中是不常见的。本文报告3例伴CNS疾病的急性早幼粒白血病(APL)。先前都用过全反式维甲酸(ATRA)治疗,考查是否这些治疗能增加髓外复发的危险。 例1,女,49岁。WBC5.3×10~9/L,形态学分类为APL,通过逆转录多聚酶链反应(RT-PCR)证实染色体易位,t(15;17)。伴bcr1(断裂点集簇一区)PML断点。经ATRA及MAE[米托蒽醌、阿糖胞苷(Arα-C)和足叶乙甙]化疗一疗程后达到形态学、细胞遗传学和分子学的缓解。在完成4个疗程的化疗
Prior to ATRA treatment, central nervous system (CNS) recurrence was uncommon in APL. This article reports three cases of acute promyelocytic leukemia (APL) with CNS disease. All previous ATRA treatment has been used to see if these treatments increase the risk of extramedullary recurrence. Example 1, female, 49 years old. WBC5.3×10~9/L, morphologically classified as APL, confirmed by chromosomal translocations by reverse transcription polymerase chain reaction (RT-PCR), t(15;17). Accompanied by bcr1 (breakpoint clustering a zone) PML breakpoint. Morphological, cytogenetic, and molecular remission were achieved after one course of chemotherapy with ATRA and MAE [Mitoxib, Ara-C, and Etoposide]. Complete 4 courses of chemotherapy