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目的探究脑出血患者出血量及神经损伤程度与血清超敏C反应蛋白(hs-CRP)及白细胞介素(IL)-6水平的关系。方法选取脑出血患者122例为观察组,另选健康体检者40例为对照组,采用多田公式计算观察组患者出血量,其中<20 ml为小量出血33例,20~40 ml为中量出血42例,>40 ml为大量出血47例,依据1995年脑血管神经功能缺损评分标准将观察组患者分为轻度损伤33例、中度损伤41例、重度损伤48例。对照组在入院1 d,观察组患者在入院1、3、7、14、30 d分别测定血清hs-CRP、IL-6水平,发病30 d后根据格拉斯哥预后评分(GOS)评价观察组患者预后。结果入院第1天观察组患者血清hs-CRP和IL-6水平均显著高于对照组(P<0.05);各个时间点随着脑出血患者出血量的增加,其血清hsCRP、IL-6水平均显著升高,差异均有统计学意义(P<0.05);各个时间点随着脑出血患者神经功能损伤的加重,其血清hs-CRP、IL-6水平均显著升高,差异均有统计学意义(P<0.05);经Spearman秩和检验显示,脑出血患者的血清hs-CRP、IL-6水平越低,其预后恢复效果越好,差异均有统计学意义(P<0.05)。结论脑出血患者血清hs-CRP、IL-6水平与脑出血量与神经损伤程度密切相关,临床检测血清hs-CRP、IL-6水平对脑出血的诊断、评估病情进展及预后有重要作用。
Objective To investigate the relationship between the amount of hemorrhage and the degree of nerve injury in patients with intracerebral hemorrhage and serum hs-CRP and interleukin-6 levels. Methods 122 cases of intracerebral hemorrhage were selected as observation group and 40 cases of healthy physical examination as control group. Tada formula was used to calculate the amount of bleeding in observation group, of which, <20 ml was minor bleeding in 33 cases and 20-40 ml was moderate Bleeding in 42 cases,> 40 ml for 47 cases of massive bleeding, according to the 1995 criteria for cerebrovascular neurological deficit in the observation group were divided into mild injury in 33 cases, moderate injury in 41 cases, severe injury in 48 cases. In the control group, the serum hs-CRP and IL-6 levels were measured at 1, 3, 7, 14 and 30 days after admission in the observation group, and the prognosis of the observation group was evaluated according to the Glasgow Outcome Scale (GOS) 30 days after the onset of disease . Results The serum levels of hs-CRP and IL-6 in the observation group were significantly higher than those in the control group on the first day after admission (P <0.05). At each time point, the levels of hsCRP and IL-6 (P <0.05). At each time point, the levels of hs-CRP and IL-6 in serum were significantly increased with the increase of neurological impairment in patients with cerebral hemorrhage at each time point, the differences were statistically significant (P <0.05). The Spearman rank sum test showed that the lower the serum hs-CRP and IL-6 levels in patients with ICH were, the better the prognosis was. The difference was statistically significant (P <0.05). Conclusion The levels of serum hs-CRP and IL-6 in patients with intracerebral hemorrhage are closely related to the amount of cerebral hemorrhage and the degree of nerve injury. The serum levels of hs-CRP and IL-6 in serum in patients with cerebral hemorrhage play an important role in the diagnosis, prognosis evaluation and prognosis of cerebral hemorrhage.