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目的 :探讨抗周围神经膜表面糖脂抗体在自身免疫介导的多发性周围神经病中的临床意义。方法 :ELISA法测定格林 巴利综合征和慢性炎性脱髓鞘性周围神经病患者血清中抗硫脂抗体和 7种节苷脂抗体 (GM1、GM2、GA1、GD1a、GD1b、GT1b和GQ1b)的阳性率。结果 :GBS和CIDP组患者抗硫脂抗体、抗GM1、GA1和GD1b抗体的阳性率显著高于非自身免疫性周围神经病组 (P <0 0 5 ) ;此两组患者间的抗体阳性率比较则无显著差异 ;GBS组内有眼 /咽肌麻痹的患者 (17例 )与无眼肌和 (或 )咽喉肌麻痹患者 (2 5例 )的节苷脂抗体阳性率也无显著差异。结论 :血清抗硫脂抗体和抗GM1抗体增高对自身免疫介导的多发性周围神经病患者有一定临床意义。
Objective: To investigate the clinical significance of anti-peripheral nerve membrane glycolipid antibodies in autoimmunity-mediated multiple peripheral neuropathy. Methods: Serum anti-sulfatide antibody and anti-sulfatibulin antibody (GM1, GM2, GA1, GD1a, GD1b, GT1b and GQ1b) in patients with Guillain-Barre syndrome and chronic inflammatory demyelinating peripheral neuropathy Positive rate. Results: The positive rates of anti-sulfolipid antibodies, anti-GM1, GA1 and GD1b antibodies in GBS and CIDP patients were significantly higher than those in non-autoimmune peripheral neuropathy patients (P <0 05). The positive rates of antibody among the two groups were compared There was no significant difference between the two groups. There was no significant difference in the positive rate of ganglioside antibodies between patients with ocular / pharyngeal paralysis (17 cases) and those without ocular muscles and / or laryngopharyngeal paralysis (25 cases) in GBS group. CONCLUSIONS: Increased serum anti-sulfolipid antibodies and anti-GM1 antibodies are of clinical significance in patients with autoimmune-mediated multiple peripheral neuropathy.