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目的研究早产儿甲状腺功能三碘甲状腺原氨酸(triiodothyronine,T3)、甲状腺素(thyroxine,T4)、促甲状腺激素(thyroid stimulating hormone,TSH)的影响因素。方法对353例早产儿生后第14天的甲状腺功能进行检测,并收集可能相关的14种因素,运用多元线性回归分析T3、T4、TSH的影响因素。结果在分析的14种因素中对早产儿生后第14天T3有影响的有胎龄、呼吸窘迫综合征(respiratory distress syndrome,RDS)、糖耐量异常,对T4有影响的有胎龄、性别,对TSH有影响的有出生体重比例、性别。结论早产是早产儿暂时性低甲状腺素血症(transient hypothyroxinemia of preterm infant,THOP)的根本原因。胎龄越小,早产儿甲状腺功能越低下。母糖耐量异常、性别、出生体重比值、呼吸窘迫综合征可能影响早产儿的甲状腺功能。
Objective To study the influencing factors of thyroid function triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) in premature infants. Methods The thyroid function of 353 preterm infants on the 14th day after birth was detected and 14 possible factors related to thyroid function were collected. The influencing factors of T3, T4 and TSH were analyzed by multivariate linear regression. Results Of the 14 factors analyzed, there were gestational age, respiratory distress syndrome (RDS), impaired glucose tolerance, and gestational age and gender , TSH have a birth weight ratio, gender. Conclusions Preterm birth is the underlying cause of transient hypothyroxinemia of preterm infant (THOP). The smaller the gestational age, the lower the thyroid function of premature children. Mum impatience, sex, birth weight ratio, and respiratory distress syndrome may affect thyroid function in preterm infants.