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核黄素在体内以FAD的形式与酶蛋白结合成各种黄素蛋白,作为电子转移系统参与氧化还原过程。核黄素缺乏时,产生皮肤、粘膜和眼部等一系列的症状。为了早期发现核黄素缺乏,及时采取防治措施,有必要进行核黄素营养状况的评定。 评定核黄素营养状况的方法很多,以往常用的主要是测定尿中核黄素的排出量,但此法收尿麻烦,影响因素多。1968年以来,试用酶的方法评价核黄素营养状况。核黄素缺乏时,红血球谷胱甘肽还原酶活性系数(Erythrocyte Glutathione Reductase Activation Coefficient简称EGRAC)迅速增高,而补充核黄素后就降为正常。Prentice等认为EGRAC是评定核黄素慢性缺乏时体内核黄素总水平的准确指标,Sauberlich等1972年已应用在营养调查中。
Riboflavin in the form of FAD with the enzyme protein into a variety of flavoproteins, as the electron transfer system involved in the redox process. Riboflavin deficiency, the skin, mucous membranes and eyes and a series of symptoms. In order to early detection of riboflavin deficiency, timely prevention and control measures, it is necessary to assess the nutritional status of riboflavin. There are many ways to assess the nutritional status of riboflavin. In the past, the most commonly used method was to determine the amount of riboflavin excreted in the urine. However, this method is troublesome to receive urine and affects many factors. Since 1968, try the enzyme method to evaluate the nutritional status of riboflavin. Erythrocyte Glutathione Reductase Activation Coefficient (EGRAC) rapidly increased when riboflavin was absent, but returned to normal after riboflavin supplementation. Prentice so that EGRAC is the accurate assessment of the overall level of riboflavin in the chronic deficiency of riboflavin accurate indicators, Sauberlich other 1972 has been used in nutritional surveys.