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已报道氢化大豆磷脂可用于控制药物的释放.释放机理可能取决于水的透入,因为氢化大豆磷脂可形成水的渗透孔隙,所以通过氢化大豆磷脂的用量可调节水的透入而达到缓释作用.作者采用氢化大豆磷脂,不加其他附加剂制成双氯灭痛缓释片(简称SR片),并进行了体内外研究.SR片的制备:取4g双氯灭痛和16g氢化大豆磷脂,两者粒径均小于74μm,混匀.加入乙醇制成糊状物,减压干燥.所得固体加以粉碎,取149～350μm颗粒压成直径为8mm,厚3mm的片剂,每片含
It has been reported that hydrogenated soya lecithin can be used to control drug release.The release mechanism may depend on the penetration of water since hydrogenated soya lecithin can form water-permeating pores so that the amount of hydrogenated soya lecithin can regulate the penetration of water to achieve sustained release The authors used hydrogenated soy lecithin, without additional additives made of diclofenac sodium sustained-release tablets (referred to as SR tablets), and conducted in vitro and in vivo.SR tablets were prepared: take 4g of diclofenac and 16g hydrogenated soy lecithin, both particle size Were less than 74μm, mixed with ethanol was added to make a paste, dried under reduced pressure The resulting solid was pulverized, granulated 149 ~ 350μm diameter 8mm, 3mm thick tablets, each containing