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目的:观察蛋白激酶C-α(protein kinase C-α,PKC-α)和B细胞淋巴瘤因子-2(B Cell Lymphoma/Leukemia-2,BCL-2)在成釉细胞瘤中的表达及其相关性,探讨其与成釉细胞瘤发生和发展的生物学意义。方法:应用免疫组织化学方法检测42例成釉细胞瘤中PKC-α和BCL-2的表达,10例牙源性角化囊肿和10例口腔正常黏膜为对照。结果:PKC-α和BCL-2在成釉细胞瘤中的阳性率均高于对照组,且PKC-α和BCL-2的表达呈正相关。结论:PKC-α和BCL-2在成釉细胞瘤中高度表达。PKC-α和BCL-2在成釉细胞瘤的发生、发展及细胞分化与增殖中起着重要作用。
OBJECTIVE: To investigate the expression of protein kinase C-α (PKC-α) and B cell lymphoma / leukemia-2 (BCL-2) in ameloblastoma Relevance, to explore its biological significance with the occurrence and development of ameloblastoma. Methods: The expressions of PKC-α and BCL-2 in 42 cases of ameloblastoma were detected by immunohistochemistry. 10 cases of odontogenic keratocyst and 10 cases of oral normal mucosa were used as controls. Results: The positive rates of PKC-α and BCL-2 in ameloblastoma were significantly higher than those in control group, and the expressions of PKC-α and BCL-2 were positively correlated. Conclusion: PKC-α and BCL-2 are highly expressed in ameloblastoma. PKC-α and BCL-2 play an important role in the development and progression of ameloblastoma and cell differentiation and proliferation.