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Apelin是孤独G蛋白耦联受体——血管紧张素受体相关蛋白的天然配体,是一种重要的生理调节肽。Apelin与血管紧张素具有同源性,属于肾素-血管紧张素系统新的组分,而肾素-血管紧张素系统能够调控心血管、肾脏及胰岛功能,参与高血压、胰岛素抵抗等疾病的发病过程。近期研究发现,Apelin是一种脂肪细胞因子,与多种代谢综合征密切相关。
Apelin is a ligand of the lonely G protein-coupled receptor, a natural ligand for angiotensin receptor-related proteins, and is an important physiologically-mediated peptide. Apelin is homologous to angiotensin and belongs to a new component of the renin-angiotensin system. The renin-angiotensin system can regulate cardiovascular, renal and pancreatic islet functions, and is involved in diseases such as hypertension and insulin resistance The course of the disease. A recent study found that Apelin is an adipocytokine and is closely related to various metabolic syndromes.