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儿童和成人在铅的摄入途径、铅代谢和铅毒性表达等方面有许多差异,儿童期铅中毒对中枢神经系统造成的损伤似乎是不可逆的。铅中毒的阈值一直没有明确的定义,美国疾病预防控制中心通常把血铅浓度0.1mg/L作为筛查基线进行风险管理。铅中毒的个体差异与遗传多态性和多种因素有关,铅对成熟器官和发育器官影响有差异,其毒性机制和毒性表达在儿童和成人不完全相同,使得成人的研究数据用于儿童受到一定的局限。
There are many differences in lead intake, lead metabolism and lead toxicity in children and adults, and damage to the central nervous system by childhood lead poisoning appears to be irreversible. The threshold for lead poisoning has not been clearly defined and the CDC routinely uses a blood lead concentration of 0.1 mg / L as a baseline for screening for risk management. Lead poisoning, individual differences and genetic polymorphism and a variety of factors, lead on mature organs and organs of development are different, the toxicity and toxicity of expression in children and adults are not exactly the same, making the adult data for children exposed Some limitations.