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了解天津市健康人群人肠道病毒71型(EV-A71)中和抗体动态变化,为手足口病防控提供依据。2009~2015年共采集5 654名天津市健康人的血清进行EV-A71中和抗体测定,结果提示EV-A71中和抗体总阳性率为82.03%,5岁及以下年龄组的抗体阳性率最低为68.28%,随着年龄增长,抗体阳性率逐年增加。不同年份、不同区域、不同年龄组间的抗体阳性率差异均有统计学意义。以健康人群EV-A71中和抗体阳性率作为应变量,对健康人群的卫生习惯及环境等进行Logistic回归分析,发现半年内未有医院出入史和饭前洗手是保护性因素。EVA71中和抗体阳性率与病原阳性率呈负相关,第一年的抗体阳性率高,第二年的EV-A71病原阳性率则低。5岁及以下儿童和流动人口较多地区应作为手足口病防控的重点,EV-A71抗体阳性率可以做为估测下一年度EV-A71引起EV-A71手足口病流行趋势的依据。
To understand the dynamic changes of neutralizing antibodies against human enterovirus 71 (EV-A71) in healthy population in Tianjin and to provide evidence for prevention and control of HFMD. A total of 5 654 healthy volunteers were collected from 2009 to 2015 to determine the neutralizing antibody of EV-A71. The results showed that the positive rate of neutralizing antibody in EV-A71 was 82.03%, and the lowest in 5 years old and below 68.28%, with the increase of age, antibody positive rate increased year by year. The positive rates of antibody in different years, different regions and different age groups were statistically significant. Taking the positive rate of neutralizing antibody of EV-A71 in healthy population as the dependent variable, Logistic regression analysis was conducted on the health habits and environment of healthy people. It was found that there was no protective factor for hospital history and washing hands before meals within six months. The positive rate of neutralizing antibody in EVA71 was negatively correlated with the positive rate of pathogen, the positive rate of antibody in the first year was high, and the positive rate of EV-A71 in the second year was low. The prevalence of EV-A71 antibody in children younger than 5 years of age and with more floating population should be the focus of hand-foot-mouth disease prevention and control. The positive rate of EV-A71 antibody can be used as the basis to estimate the epidemic trend of EV-A71 hand-foot-mouth disease in the next year.