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周围血中的白细胞是宿主对细菌和真菌的第一道防线。这主要是吞噬细胞特别是嗜中性粒细胞的作用。周围血或骨髓中吞噬细胞减少,或吞噬功能失常,就会导致慢性和反复的细菌或真菌感染。从骨髓干细胞经过原始粒细胞、早幼粒细胞阶段,发育到中幼粒和晚幼粒阶段时已具有吞噬能力,但要成熟到多形核中性粒细胞(PMN)时才有最大的吞噬功能。从晚幼粒发育成杆状核再到PMN需要6～7天。循环中的PMN的半衰期约为6～7个小时。周围血中粒细胞数降到每立方毫米1500个以下时,即称为嗜中性粒细胞减少症。粒细胞生成的障碍
White blood cells in the surrounding blood are the host’s first line of defense against bacteria and fungi. This is mainly the role of phagocytic cells, especially neutrophils. Reduced phagocytosis of peripheral blood or bone marrow, or dysfunctional phagocytosis, can lead to chronic and recurrent bacterial or fungal infections. From bone marrow stem cells through the primordial granulocytes, promyelocytic stage, the development of the juvenile and late promyelocytic stage has phagocytic capacity, but to mature to polymorphonuclear neutrophils (PMN) when the largest phagocytosis Features. It takes 6 to 7 days to grow PM from PM to PMN. The half-life of PMN in circulation is about 6 to 7 hours. Peripheral blood neutropenia dropped to 1,500 per cubic millimeter below, known as neutropenia. Barrier to granulocytosis