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本文报告运用硫酸镁药代动力学原理,拟定两种给药方案,用于治疗重度先兆子痫患者46例,并与对照组方案Ⅰ进行比较。Ⅰ,Ⅱ,Ⅲ组三种方案治疗前的血压无显著差异(P>0.05)。治疗后血压分别降低23.5±2.3/11.3±1.9,27.1±2.0/18.9±1.8及34.3±2.2/23.3±0.9mmHg,有极显著差异(P<0.01),治疗后症状改善所需时间分别为136.3±13.0、19.4±2.6及29.4±1.1min,有极显著差异(P<0.01)。两种方案均优于对照组,尤以方案Ⅲ更为适宜。观察到硫酸镁治疗重度先兆子痫时,血镁水平达3mEq/1即显效,有效浓度范围在3.5—6mEq/1。镁在体内主要经肾脏排泄,自用药起24小时尿镁回收率达80%以上,认为患者每小时尿量>50ml,治疗是安全的。
This article reports the use of magnesium sulfate pharmacokinetics principles, the development of two dosing regimens for the treatment of 46 cases of severe preeclampsia patients, and compared with the control group Ⅰ. There was no significant difference in the blood pressure before treatment among Ⅰ, Ⅱ and Ⅲ groups (P> 0.05). After treatment, the blood pressure decreased by 23.5 ± 2.3 / 11.3 ± 1.9, 27.1 ± 2.0 / 18.9 ± 1.8 and 34.3 ± 2.2 / 23.3 ± 0.9mmHg respectively, with significant difference (P <0.01). The time needed for improvement of symptoms after treatment was 136.3 ± 13.0, 19.4 ± 2.6 and 29.4 ± 1.1min respectively, with significant difference (P <0.01). Two kinds of programs are better than the control group, especially in the program Ⅲ is more appropriate. Magnesium sulfate was observed in patients with severe preeclampsia, blood magnesium level of 3mEq / 1 markedly effective range of effective concentration 3.5-6mEq / 1. Magnesium in the body mainly by the kidneys excretion, since the drug from 24 hours urine magnesium recovery rate of 80% or more, that the patient per hour urine output> 50ml, the treatment is safe.