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促性腺激素释放激素(GnRH)脉冲治疗是通过静脉滴注或者皮下给药的方式连续脉冲式给予 GnRH 类似物,兴奋垂体产生接近生理性的促性腺激素脉冲,进一步促进性腺发育,合成性激素并维持生殖细胞发育及成熟。GnRH 脉冲治疗尤其适用于下丘脑病变,且垂体功能正常而导致的低促性腺激素型性腺功能减退症(IHH)患者,GnRH 脉冲治疗方案最接近下丘脑-垂体-性腺轴的生理调节机制,可以模拟正常的生理模式产生内源性的正、负反馈调节。GnRH 脉冲治疗是治疗不孕不育的满意方法,也是目前学者研究的热点。笔者拟就 GnRH 脉冲分泌的特点,GnRH 脉冲治疗的应用、治疗剂量和频率、影响因素、优点及缺点进行综述如下。“,”Pulsatile gonadotrophin releasing hormone (GnRH)therapy is to stimulate pituitary gland to produce physiological gonadotropin by ntravenous or subcutaneous infusion which giving GnRH analogue in pulsation.Sequentially,gonadotropin could promote development of gonad,compound sex hormone, make reproductive cell growth and mature.Pulsatile GnRH therapy is particularly appropriate for patients with idiopathic hypogonadotropic hypogonadism (IHH)whose lesion is located hypothalamus with normal pituitary function.Pulsatile GnRH therapy could produce physiological positive and negative regulation, which are adjacent to physiological regulation mechanism in hypothalamic-pituitary-gonadal axis.Pulsatile GnRH therapy is a good way to treat infertility,becoming a research focus.This article reviews literatures on the characteristics,clinical applications,therapeutic dosage and frequency,influence factors,advantages and disadvantages of pulsatile GnRH therapy.