【摘 要】
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The effect and mechanism of phenylacetic acid on the proliferation of pancreatic carcinoma cells were investigated in cultured pancreatic carcinoma BXPC-3 cells
【机 构】
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Department of General Surgery,Department of Thyroid Gland Surgery,Prostate Diseases Prevention and T
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The effect and mechanism of phenylacetic acid on the proliferation of pancreatic carcinoma cells were investigated in cultured pancreatic carcinoma BXPC-3 cells by means of 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide assay and flow cytometry assay. The results show that the treatment of pancreatic carcinoma cells with phenylacetic acid significantly inhibited the cell proliferation in time-dependent and dose-dependent manners. The proliferation of BXPC-3 cells was inhibited at the stage of S phase, the cells at the end stage of S phase were accumulated abundantly, and thus DNA synthesis could not be accomplished entirely. In addition, the expression of adenosine deaminases acting on RNA(ADARs) mRNA in BXPC-3 cells and pancreatic carcinoma specimen were detected by RT-PCR. Having been treated with phenylacetic acid, ADAR2 mRNA in BXPC-3 cells was significantly decreased, the differences were of statistical significance(P
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