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目的观察高血压前期患者血清同型半胱氨酸(Hcy)水平的变化及其与动脉粥样硬化的关系。方法选取高血压前期患者65例设为观察组A,选取同期原发性高血压患者69例设为观察组B,选取同期体检血压正常者72例设为对照组。观察比较三组血清Hcy水平、血脂水平、颈总动脉内膜中层厚度(IMT)及其相关性。结果观察组A、B血清Hcy水平、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、IMT与对照组比较,差异有统计学意义(P<0.05);观察组A、B间的Hcy、TC、IMT比较,差异有统计学意义(P<0.05),观察组A患者血清Hcy水平、IMT与患者血压呈现明显正相关(r=0.47、0.46,P<0.05),血清Hcy水平与IMT也呈现明显正相关(r=0.51,P<0.05)。观察组A中内膜增厚者和内膜斑块形成者Hcy水平均高于IMT正常者,差异有统计学意义(P<0.05)。结论高血压前期患者血清Hcy水平升高,血压水平、IMT也同步增高,随着Hcy的升高发展为动脉粥样硬化的危险也增高,因此,应重视对高血压前期患者的Hcy水平变化的筛查,并做出有效防治,对减少动脉粥样硬化的发生有重要的临床意义。
Objective To observe the changes of serum homocysteine (Hcy) level and its relationship with atherosclerosis in prehypertensive patients. Methods Sixty-five patients with prehypertension were selected as observation group A. A total of 69 patients with essential hypertension in the same period were selected as observation group B. 72 patients with normal blood pressure during the same period were selected as control group. The levels of serum Hcy, blood lipid, carotid artery intima-media thickness (IMT) and their correlation were observed and compared. Results The levels of Hcy, LDL-C, TC and IMT in observation group A and B were significantly different from those in control group (P <0.05). Between observation group A and B (P <0.05). There was a significant positive correlation between serum Hcy levels and IMT in patients with A (P <0.05), but there was a significant positive correlation between IMT and blood pressure (r = 0.47,0.46, P < And IMT also showed a significant positive correlation (r = 0.51, P <0.05). Hcy levels in intimal thickening and intimal plaque formation in observation group A were higher than those in normal IMT group, with significant difference (P <0.05). Conclusions Patients with prehypertensive serum levels of Hcy increased, blood pressure levels, IMT also increased simultaneously with the rise of Hcy, the risk of developing atherosclerosis also increased, therefore, should pay attention to changes in prehypertensive patients with Hcy levels Screening, and make effective prevention and treatment, to reduce the occurrence of atherosclerosis has important clinical significance.