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目的:观察灌胃五虎汤制剂后大鼠体内出现的6种化学成分麻黄碱、甘草酸、甘草次酸、龙脑、松油醇、苯乙醇的平喘作用。方法:采用豚鼠离体气管螺旋条法筛选6种化学成分的平喘作用。结果:6种物质对组胺所致豚鼠气管平滑肌的收缩均有抑制作用。结论:以上成分为五虎汤平喘作用的物质基础。
OBJECTIVE: To observe the anti-asthmatic effect of six chemical constituents of ephedrine, glycyrrhizic acid, glycyrrhetinic acid, borneol, terpineol, and phenylethyl alcohol that appeared in rat body after the administration of gavage Wuhu Decoction. METHODS: The anti-asthmatic effects of six chemical components were screened by using the isolated tracheal spiral strip method of guinea pigs. Results: Six substances inhibited the contraction of tracheal smooth muscle in guinea pigs caused by histamine. Conclusion: The above ingredients are the material basis for the anti-asthma effect of Wu Hu Tang.