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用体外试验方法,观察雷公藤多甙对T细胞白细胞介素-2(IL-2)自泌环路的影响。结果表明,雷公藤多甙对T细胞的激活、IL-2的产生、IL-2R的表达和活化T细胞对IL-2的反应性均有抑制作用。
The effect of tripterygium wilfordii on the self-secretion loop of T-cell interleukin-2 (IL-2) was observed in vitro. The results showed that TWP could inhibit the activation of T cells, the production of IL-2, the expression of IL-2R, and the reactivity of activated T cells to IL-2.