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机体在大剂量、长时间的口服两歧双歧杆菌后才能在其血清中检出特异性抗体，而非正常寄居菌沙门氏菌则在经四摄取后很短时间内，产生较高水平的特异性抗体，并维持较长的时间。可以认为尽管摄入的双歧杆菌数量很大，一般不易引起宿主产生抗体，即使产生抗体也是低水平的，或在短时间内有一定的反应，之后很快便消失。进一步的研究表明，在体外诱导脾细胞的产生免疫应答的细胞数量上，双歧杆菌的数量是沙门氏菌的20倍。由此推论，两歧双歧杆菌经口服后具有较弱的免疫原性。
The body in high-dose, prolonged oral Bifidobacterium Bifidobacterium in the serum after detection of specific antibodies, while the non-normal Sj. Salmonella in a very short period of time after four ingestion, have a high level of specificity Antibody, and maintain a longer time. It is believed that despite the large amount of bifidobacteria ingested, it is generally not easy for the host to produce antibodies, and even if the antibody is produced, it is low-level or has a certain response in a short period of time and disappears very quickly. Further studies showed that the number of Bifidobacteria that are induced in vitro in spleen cells to produce an immune response is 20 times more than that of Salmonella. It follows that Bifidobacterium bifidum has weaker immunogenicity after oral administration.