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目的:探讨早期干预对无周围神经症状的早期糖尿病周围神经病预后的影响。方法:选择100例无周围神经症状但神经传导速度测定已有异常的2型糖尿病患者,将其随机分为干预组与对照组各50例,干预组予神经营养剂甲钴铵、VitB1等治疗,对照组予随访。结果:干预后观察干预组出现临床症状、体征例数明显少于对照组,干预组神经传导速度前后比较有明显差异,且与对照组比较也有明显差异。结论:对无周围神经症状的早期糖尿病周围神经病积极干预可能逆转周围神经损害。
Objective: To investigate the effect of early intervention on the prognosis of early diabetic peripheral neuropathy without peripheral nerve symptoms. Methods: 100 type 2 diabetic patients with no peripheral neurological symptoms but abnormal nerve conduction velocity were selected and randomly divided into intervention group and control group with 50 cases each. The intervention group was treated with neurotrophic drugs such as methylcobalamin and VitB1 , Control group were followed up. Results: After intervention, the clinical symptoms and the number of signs in the intervention group were significantly less than those in the control group. There were significant differences in the nerve conduction velocity between the intervention group and the control group. Conclusion: Positive intervention for early diabetic peripheral neuropathy without peripheral neuropathy may reverse peripheral nerve damage.