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目的 :寻找有效的多药耐药逆转剂。方法 :以 O6 -苄基鸟嘌呤 (O6 - BG)作为耐药逆转剂 ,用 MTT法体外药物敏感试验 ,观察 0 6 - BG对多药耐药白血病细胞株 K5 6 2 / DOX的药物敏感性的影响。结果 :O6 - BG可增强阿霉素 (DOX)对 K5 6 2 / DOX及 K5 6 2的细胞毒作用。结论 :O6 - BG是一种有效的多药耐药逆转剂。
Objective: To find an effective multidrug resistance reversal agent. METHODS: O6-benzylguanine (O6-BG) was used as a drug resistance reversal agent. MTT assay was used to detect drug sensitivity in vitro. The drug sensitivity of 0 6 - BG to multidrug resistant leukemia cell line K5622/DOX was observed. Impact. RESULTS: O6-BG enhanced the cytotoxicity of DOX against K562/DOX and K562. Conclusion : O6 - BG is an effective multidrug resistance reversal agent.