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目的探讨二甲双胍治疗非酒精性脂肪肝(NAFLD)的疗效及安全性。方法将84例NAFLD患者随机分为两组,对照组给予饮食控制,同时给予甘草酸二胺;治疗组在对照组的基础上,加用二甲双胍,疗程均为8周。对两种方案的临床症状、肝功能、血脂和B超脂肪肝声像图改善情况进行对比研究。结果治疗组临床症状、肝功能、血脂和B超脂肪肝声像图改善程度优于对照组。结论二甲双胍治疗NAFLD有效、安全。
Objective To investigate the efficacy and safety of metformin in the treatment of non-alcoholic fatty liver disease (NAFLD). Methods Eighty-four patients with NAFLD were randomly divided into two groups. The control group was given diet control and glycyrrhizic acid diamine. The treatment group was treated with metformin on the basis of the control group for 8 weeks. The clinical symptoms, liver function, blood lipid and ultrasound of B-steatosis were compared between the two regimens. Results The clinical symptoms, liver function, blood lipids and B-ultrasound of the fatty liver in the treatment group were better than those in the control group. Conclusion Metformin is effective and safe in treating NAFLD.