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目的观察地榆升白片对缓解结直肠癌化疗中白细胞减少的临床疗效。方法 138例患者随机分为两组,治疗组化疗期间采用地榆升白片加利血生片治疗,对照组化疗期间采用利血生片治疗,比较两组患者化疗前及化疗后第7、14、21天白细胞计数以及化疗前后对患者进行Karnofsky(卡氏,KPS,百分法)功能状态评分。结果两组患者在化疗结束后第7、14、21天白细胞减少发生率,治疗组明显低于对照组,比较有统计学差异(P<0.01);治疗组治疗显效例数53例,好转为15例,无效为1例。对照组显效为31例,好转为29例,无效为1例。两组疗效的比较有极显著差异(P<0.01);化疗前后两组KPS评分变化情况的比较有极显著差异(P<0.01)。结论地榆升白片对结直肠癌患者化疗中白细胞减少有着显著的疗效,并且有效地改善患者化疗过程中相关临床症状。
Objective To observe the clinical efficacy of Diyu Shengbai Tablets on alleviating leukopenia in patients with colorectal cancer. Methods One hundred and thirty-eight patients were randomly divided into two groups. The treatment group was treated with Ulmus officinalis or gliclazide, while the control group was treated with reserpine. During the chemotherapy, The white blood cell counts on 14, 21 days and Karnofsky (Karnofsky, KPS, percent) functional status scores before and after chemotherapy. Results The incidence of leukopenia on the 7th, 14th and 21st day after chemotherapy in the two groups was significantly lower than that in the control group (P <0.01). The effective rate of the treatment group was 53 15 cases, invalid in 1 case. The control group was markedly effective in 31 cases, improvement in 29 cases, invalid in 1 case. There was significant difference between the two groups (P <0.01). There was significant difference in KPS scores between the two groups before and after chemotherapy (P <0.01). Conclusion Diyu Shengbai Tablet has a significant effect on chemotherapy of leucopenia in patients with colorectal cancer, and effectively improve the clinical symptoms of patients during chemotherapy.