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目的检测冠心病(CHD)患者活化蛋白C敏感率(APC-SR)并计算活化蛋白C抵抗(APCR)阳性率,探讨APC-SR及APCR在CHD中的临床意义。方法选取2006年1月至7月华中科技大学同济医学院附属协和医院心内科住院的56例CHD患者为研究对象,对照组为同期在本院耳鼻喉科住院的患者54例,采用全自动血凝分析仪测定APC-SR,计算APCR阳性率;同时采用免疫酶联吸附试验检测血浆中蛋白C、总蛋白S和游离蛋白S。结果CHD患者APC-SR平均值(2.44±0.18)显著低于对照组(2.68±0.15)(P<0.01);CHD组APCR阳性率与对照组比较,差异无显著性意义。CHD组APC-SR<2.4的阳性率显著高于对照组(P<0.01)。蛋白C、总蛋白S和游离蛋白S在CHD组和对照组之间差异无显著性意义。结论低水平APC-SR与CHD的发病相关,可考虑将该指标作为CHD危险人群的筛查指标。
Objective To detect the activation rate of activated protein C (APC-SR) in patients with coronary heart disease (CHD) and calculate the positive rate of activated activated protein C resistance (APCR), and to explore the clinical significance of APC-SR and APCR in CHD. Methods 56 CHD patients hospitalized in the Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 2006 to July 2006 were selected as the study subjects. The control group consisted of 54 hospitalized patients with otolaryngology in our hospital during the same period. The APC-SR was measured by the coagulation analyzer and the APCR positive rate was calculated. Meanwhile, protein C, total protein S and free protein S in plasma were detected by enzyme-linked immunosorbent assay. Results The average APC-SR in CHD patients was significantly lower than that in control group (2.44 ± 0.18) (2.68 ± 0.15) (P <0.01). The positive rate of APCR in CHD group was not significantly different from that in control group. The positive rate of APC-SR <2.4 in CHD group was significantly higher than that in control group (P <0.01). There was no significant difference in protein C, total protein S and free protein S between CHD group and control group. Conclusions Low-level APC-SR is associated with the pathogenesis of CHD, and may be considered as a screening index for risk groups of CHD.