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目的:探讨睡眠呼吸暂停和子痫前期的相关性。方法:收治子痫前期合并SAHS孕妇25例作为观察1组,子痫前期无SAHS孕妇40例作为观察2组,选取25例正常孕妇作为对照组。比较3组呼吸暂停低通气指数、最低血氧饱和度、IL-6和TNF-α。结果:对照组AHI和LSaO_2与观察2组比较,差异无统计学意义(P>0.05)。对照组AHI和LSaO_2与观察1组比较,差异具有统计学意义(P<0.05)。对照组TNF-α、IL-6与观察2组比较,差异具有统计学意义(P<0.01)。观察1组TNF-α、IL-6与对照组比较,差异具有统计学意义(P<0.01)。结论:睡眠呼吸暂停是子痫前期疾病发生的危险因素。
Objective: To investigate the relationship between sleep apnea and preeclampsia. Methods: Twenty-five pregnant women with preeclampsia and SAHS were enrolled in this study. Forty pregnant women with preeclampsia without SAHS were selected as observation group and 25 normal pregnant women as control group. The apnea hypopnea index, the lowest oxygen saturation, IL-6 and TNF-α were compared between the three groups. Results: There was no significant difference between AHI and LSaO_2 in control group and observation group 2 (P> 0.05). The control group AHI and LSaO_2 compared with the observation group 1, the difference was statistically significant (P <0.05). The difference of TNF-α and IL-6 between the two groups was statistically significant (P <0.01). The difference of TNF-α and IL-6 between the two groups was statistically significant (P <0.01). Conclusion: Sleep apnea is a risk factor for preeclampsia.