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目的探讨糖尿病（DM）患者病情控制前后血浆内皮素（gr）浓度改变及M与DM慢性血管并发症的关系。方法测定50例DM患者血浆血浓度及血糖、果糖胺（F7AI）、DM血管并发症积分等相关指标，选择正常对照组30例。结果DM患者血糖控制前、后血浆血浓度均显著高于对照组（P＜0．0），有并发症者见浓度显著高于无并发症者（P＜0．01）；治疗前后血浆血浓度与刚开发症严重程度、f3：M呈显著正相关，而与病程血糖不存在显著性相关；治疗后血糖浓度显著下降（P＜0刀1），但血浆m浓度下降不显著。结论①血浆血浓度：规患者显著高于对照组；有开发症者显著高于无并发症者；②血浆阿浓度与DM慢性血管并发症严重程度、FTFM浓度呈显著正相关；③短期内血浆M浓度不因血糖浓度显著下降而显著降低。
Objective To investigate the changes of plasma endothelin (gr) concentrations in patients with diabetes mellitus (DM) before and after treatment and the relationship between M and chronic vascular complications. Methods 50 cases of DM patients with plasma blood concentration and blood glucose, fructosamine (F7AI), DM vascular complications and other related indicators, select the normal control group of 30 patients. Results The blood plasma concentrations of DM patients before and after glycemic control were significantly higher than those of the control group (P <0.0), and those with complications were significantly higher than those without complications (P <0.01) There was a significant positive correlation between the concentration and the severity of newly developed disease, f3: M, but not with the duration of glycemia. The blood glucose concentration decreased significantly after treatment (P <0.05), but the plasma m concentration did not decrease significantly. Conclusions ① The plasma concentration of blood: the patients in the control group were significantly higher than those in the control group; those with developmental diseases were significantly higher than those without complications; ② There was a significant positive correlation between plasma A concentration and the severity of DM chronic vascular complications and FTFM concentration; ③ Short- M concentration is not significantly reduced due to a significant decrease in blood glucose levels.