文献报道对酰基辅酶A-胆固醇酰基转移酶(ACAT)的抑制是预防和治疗高胆固醇血症和动脉粥样硬化的重要指标。在从天然植物寻找ACAT抑制剂的研究过程中,发现日本厚朴(Magnolia obovata)叶提取物能显著抑制ACAT的活性,在100μg/ml时对大鼠肝ACAT的抑制率为62％。已知日本厚朴的皮在朝鲜、中国、日本作为药用已有数百年的历史,但发现日本厚朴叶作为降脂药还 The literature reports that inhibition of acyl-CoA-cholesterol acyltransferase (ACAT) is an important indicator for the prevention and treatment of hypercholesterolemia and atherosclerosis. In the search for ACAT inhibitors from natural plants, it was found that Magnolia obovata leaf extract can significantly inhibit the activity of ACAT, and the inhibition rate of liver ACAT in rats at 100 μg/ml was 62%. It is known that the skin of Japanese Magnolia officinalis has been used for medicinal purposes in North Korea, China, and Japan for hundreds of years, but it has been found that Japanese Magnolia leaves are used as lipid-lowering drugs.