本文用尿药浓度法测定六名志愿者单剂量口服国产、进口两种氧氟沙星片剂的尿药浓度,结果表明:国产与进口两种片剂具有相同的药动学特征及生物等效性。其药动学参数分别为:k(h~(-1)):0.1185、0.1180;T_(1/2)(h):5.94、6.11;(?)—24(mg):174.66、167.79;排泄率:87.33%、83.89% Urinary drug concentration method was used to determine urinary drug concentrations of six domestic volunteers and two imported ofloxacin tablets in six volunteers. The results showed that both domestic and imported tablets had the same pharmacokinetic characteristics and bioavailability Validity. The pharmacokinetic parameters were as follows: k (h -1): 0.1185,0.1180; T 1/2 (h): 5.94,6.11; (?) - 24 (mg): 174.66,167.79; Rate: 87.33%, 83.89%