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目的探讨与研究高血压合并阻塞性睡眠呼吸暂停低通气综合征患者临床特征及其相关心血管危险因素。方法将我院收治的高血压合并阻塞性睡眠呼吸暂停低通气综合征的患者作为研究对象,依据患者合并阻塞性睡眠呼吸暂停低通气综合征病情程度共分为4组,回顾性分析各组患者临床相关特征及其心血管危险因素,并进行统计学分析。结果Ⅰ组患者平均年龄、BMI、AHI及总胆固醇均低于其他三组,差别有统计学意义,P<0.05;Ⅲ组患者平均年龄、AHI、LDL-C均高于Ⅱ组,P<0.05;随着患者病情严重程度的增加,高血脂、高血糖、吸烟、高敏C反应蛋白及肥胖出现率增加,统计分析有统计学差异,P<0.05;回归分析发现高血压合并OSAHS相关危险因素包括性别、年龄、BMI、早发心血管疾病及空腹血糖。结论研究发现高血压合并OSAHS患者临床发病心血管危险因素包括肥胖、糖脂代谢紊乱等,其中高血压合并OSAHS重度患者是心血管危险因素的常见人群,其他如BMI及性别也与OSAHS有密切关系。
Objective To investigate and study the clinical characteristics of hypertensive patients with obstructive sleep apnea-hypopnea syndrome and its associated cardiovascular risk factors. Methods Hypertension patients with obstructive sleep apnea-hypopnea syndrome admitted to our hospital were divided into four groups according to the severity of obstructive sleep apnea-hypopnea syndrome. Retrospective analysis of patients in each group Clinically relevant characteristics and cardiovascular risk factors, and statistical analysis. Results The average age, BMI, AHI and total cholesterol in group Ⅰ were significantly lower than those in the other three groups (P <0.05). The mean age, AHI and LDL-C in group Ⅲ were significantly higher than those in group Ⅱ, P <0.05 ; With the severity of the patients increased, the incidence of hyperlipidemia, hyperglycemia, smoking, high-sensitivity C-reactive protein and obesity increased statistically statistical difference P <0.05; regression analysis found that hypertension associated OSAHS risk factors include Sex, age, BMI, premature cardiovascular disease and fasting glucose. Conclusions The study found that cardiovascular risk factors in patients with hypertension and OSAHS include obesity, dyslipidemia and so on. Hypertensive patients with severe OSAHS are common cardiovascular risk factors. Others such as BMI and gender are also closely related to OSAHS .