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目的分析注射用门冬氨酸洛美沙星药物不良反应/事件(ADR/ADE)发生的类型及特点,为临床合理用药提供参考。方法对2008年1月1日～2011年7月30日收集到的46例注射用门冬氨酸洛美沙星ADR/ADE报告,从患者情况、不良反应的临床表现、原患疾病及因果关系的评价等方面进行回顾性统计分析。结果 46例注射用门冬氨酸洛美沙星ADR/ADE报告中,女性多于男性;累及的系统-器官主要是皮肤及其附件、消化系统、中枢神经系统、光敏反应、呼吸系统等;主要发生在用药后5～40min内,多数患者在停药后1d内康复或明显好转。结论应重视注射用门冬氨酸洛美沙星用药后的监护,减少或者避免严重ADR/ADE的发生,确保临床安全、有效、合理用药。
Objective To analyze the types and characteristics of ADR / ADR injections and provide a reference for clinical rational drug use. Methods A total of 46 ADR / ADE reports of aspartate Lomefloxacin Injection collected from January 1, 2008 to July 30, 2011 were collected from the patients, the clinical manifestations of the adverse reactions, the original disease and causation Evaluation and other aspects of retrospective statistical analysis. Results In 46 ADR / ADE reports, there were more females than males in the report of Lomefloxacin aspartate injection. The main systems involved were skin and its appendages, digestive system, central nervous system, photoreaction and respiratory system. The main Occurred within 5 ~ 40min after treatment, the majority of patients recover within 1d after withdrawal or significantly improved. Conclusions The monitoring of lomefloxacin aspartate injection should be taken seriously to reduce or avoid the occurrence of severe ADR / ADE, so as to ensure clinical safety, effectiveness and reasonable medication.