论文部分内容阅读
目的探讨美托洛尔注射液对冠状动脉(冠脉)心肌桥的影响,临床疗效和安全性。方法选择2011年5月至2013年5月心内科住院,通过冠脉造影确诊为冠脉心肌桥患者72例,观察并比较静脉注射美托洛尔注射液5,10 min后患者血压、心率及心肌桥收缩期狭窄程度的变化用配对t检验比较。结果用药前与用药后相比美托洛尔使冠脉狭窄程度由用药前的70.0%±18.2%降至用药后的46.4%±18.5%(t=7.701,P<0.01);心率由(75.5±7.0)次/min下降至(65.3±6.8)次/min(t=8.814,P<0.01);收缩压由(139±16)mmHg下降至(128±14)mmHg(t=4.280,P<0.01),舒张压由(75±8)mmHg下降至(66±4)mmHg(t=7.967,P<0.01),用药前后相比差异均有统计学意义。结论美托洛尔注射液治疗心肌桥是有效的安全的,可以减轻心肌桥对冠脉的压迫使狭窄程度减轻。
Objective To investigate the effect, clinical efficacy and safety of metoprolol injection on myocardial bridge of coronary artery (coronary artery). Methods From May 2011 to May 2013, 72 patients with coronary myocardial bridge were diagnosed by coronary angiography in our hospital from May 2011 to May 2013. The blood pressure, heart rate and blood pressure were measured at 5 and 10 minutes after intravenous metoprolol injection Myocardial bridge systolic stenosis changes compared with the paired t test. Results Before treatment, metoprolol reduced the severity of coronary artery stenosis from 70.0% ± 18.2% before treatment to 46.4% ± 18.5% (t = 7.701, P <0.01), and the heart rate decreased from (75.5 ± Systolic blood pressure decreased from (139 ± 16) mmHg to (128 ± 14) mmHg (t = 4.280, P <0.01) ). The diastolic blood pressure decreased from (75 ± 8) mmHg to (66 ± 4) mmHg (t = 7.967, P <0.01). There were significant differences between before and after treatment. Conclusion Metoprolol injection is effective and safe for the treatment of myocardial bridge, which can relieve the compression of coronary artery bridge and reduce the degree of stenosis.