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目的探讨不明原因复发性流产与男方精子DNA完整性的关系。方法精子DNA完整性检测采用精子染色质扩散试验(sperm chromatin dispersion,SCD),以DNA断裂指数(DNA fragmentation index,DFI)表示。分别对不明原因复发性流产男方与无流产史男方精子进行精液常规分析和DFI分析。结果流产组精子密度、活动率、前向运动率和DFI与生育组比较差异有统计学意义(P<0.05)。结论不明原因复发性流产可能与精子DNA损伤存在一定关系。
Objective To investigate the relationship between unexplained recurrent spontaneous abortion and male sperm DNA integrity. Methods Sperm DNA integrity testing was performed using sperm chromatin dispersion (SCD) and DNA fragmentation index (DFI). Respectively, unexplained recurrent spontaneous abortion and men with no history of menstrual sperm routine sperm analysis and DFI analysis. Results There were significant differences in sperm density, activity rate, forward movement rate and DFI between the abortion group and the reproductive group (P <0.05). Conclusions unexplained recurrent spontaneous abortion may be related to DNA damage in sperm.