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他克莫司(FK-506)作为一种新型免疫抑制剂,已广泛应用于器官移植术后。有研究表明,FK-506可能损害肠黏膜屏障功能,但机制不明。现将关于FK-506对肠黏膜屏障功能的影响作一综述,为进一步研究其分子机制提供理论依据。
Tacrolimus (FK-506) has been widely used as a new immunosuppressive agent after organ transplantation. Studies have shown that FK-506 may damage the intestinal mucosal barrier function, but the mechanism is unknown. Now on FK-506 on the intestinal mucosal barrier function are reviewed, to provide a theoretical basis for further study of its molecular mechanism.