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探讨活血定痛汤联合西药应用于心脉瘀阻型冠心病心绞痛临床治疗中效果分析,为临床应用提供参考。方法:选取南阳市第九人民医院2015年1月至2017年1月所收治心脉瘀阻型冠心病心绞痛患者86例,随机分为研究组和对照组。对照组43例,予以抗心绞痛、降压等西药对症支持治疗;研究组43例,加用活血定痛汤。比较两组患者临床疗效、治疗前后血清C反应蛋白(CRP)浓度及不良反应发生情况。结果:研究组加用活血定痛汤后,显效28例、有效13例,其临床总有效率为95.35%,显著优于对照组的18例、15例及76.74%,组间比较,差异具有统计学意义(P<0.05)。治疗前,两组患者血清CRP浓度比较,差异均无统计学意义(P>0.05);治疗后,两组均较治疗前有显著下降,差异具有统计学意义(P<0.01),其中,研究组血清CRP浓度为(6.39±1.31)mg·L~(-1),显著低于对照组的(12.25±3.17)mg·L~(-1),差异具有统计学意义(P<0.01)。研究组不良反应发生率为4.65%,低于对照组的11.63%,组间比较,差异无统计学意义(P>0.05)。两组不良反应症状均较轻,经对症处理缓解。结论:活血定痛汤联合西药应用于心脉瘀阻型冠心病心绞痛临床治疗中疗效肯定,效果持久,用药安全性高。
To investigate the effect of Huoxuedingtong decoction combined with western medicine in clinical treatment of coronary heart disease with angina pectoris and coronary heart disease, and provide reference for clinical application. Methods: Totally 86 patients with coronary heart disease and angina pectoris were admitted to Ninth People’s Hospital of Nanyang City from January 2015 to January 2017. They were randomly divided into study group and control group. Control group, 43 cases, to be anti-angina, antihypertensive Western symptomatic and supportive treatment; study group 43 cases, plus Huoxuedingtongtang. The clinical efficacy, serum C-reactive protein (CRP) concentration and adverse reactions before and after treatment were compared between the two groups. Results: The study group added Huoxuendingtongtang, markedly effective in 28 cases, effective in 13 cases, the total effective rate was 95.35%, significantly better than the control group of 18 cases, 15 cases and 76.74%, the difference between the groups Statistical significance (P <0.05). Before treatment, there was no significant difference in serum CRP concentrations between the two groups (P> 0.05). After treatment, both groups had a significant decrease compared with that before treatment (P <0.01), of which, The level of serum CRP was (6.39 ± 1.31) mg · L -1, which was significantly lower than that of the control group (12.25 ± 3.17) mg · L -1. The difference was statistically significant (P <0.01). The incidence of adverse reactions in the study group was 4.65%, which was 11.63% lower than that in the control group. There was no significant difference between the two groups (P> 0.05). Two groups of adverse reactions were mild symptoms alleviated by symptomatic treatment. Conclusion: Huoxuedingtong decoction combined with western medicine is effective in clinical treatment of angina pectoris with coronary heart disease and angina pectoris. The effect is durable and the medication is safe.