Mesial temporal lobe epilepsy (mTLE),the most common type of focal epilepsy,is associated with functional and structural brain alterations.Machine learning (ML) techniques have been successfully used in discriminating mTLE from healthy controls.However,either functional or structural neuroimaging data are mostly used separately as input,and the opportunity to combine both has not been exploited yet.We conducted a multimodal ML study based on functional and structural neuroimaging measures.We enrolled 37 patients with left mTLE,37 patients with right mTLE,and 74 healthy controls and trained a support vector ML model to distinguish them by using each measure and the combinations of the measures.For each single measure,we obtained a mean accuracy of 74％ and 69％ for discriminating left mTLE and right mTLE from controls,respectively,and 64％ when all patients were combined.We achieved an accuracy of 78％ by integrating functional data and 79％ by integrating structural data for left mTLE,and the highest accuracy of 84％ was obtained when all functional and structural measures were combined.These findings suggest that combining multimodal measures within a single model is a promising direction for improving the classification of individual patients with mTLE.