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1 背景 碘化罂粟油于1901年用于临床,最初作为器官造影剂使用(气管、肝、肾、输卵管等),放射性标记的碘化罂粟油还用于肝癌的治疗和代谢检查。鉴于碘化油的稳定性,尽管有毒性反应或副作用的报道,但还得到了很好的应用,碘油用于碘缺乏病(IDD)的防治始于1959年,主要由Clarke,McCullagh,Buttfield和Hetzel在巴布亚新几内亚的病区使用;1966年起在南美和非洲使用。我国北京医科大学张昌颖于1956年用自制碘化豆油来防治大鼠实验性甲状腺肿;1957年方昕用于大别山区的地甲病防治;1978年在我国碘缺乏病区开始了较大范围的碘油防治工作。目前世界上生产用于防治IDD的碘油的厂家主要有两个,一个是法国的Guerbet和我国的武汉第四制药厂。据悉印尼也要兴建一个碘油厂。
BACKGROUND Iodized poppy oil was used clinically in 1901 and was originally used as an organ contrast agent (trachea, liver, kidney, fallopian tubes, etc.). Radioactively labeled poppy oil was also used in the treatment and metabolic tests of liver cancer. In view of the stability of iodized oil, despite the toxic reactions or side effects reported, but also been very well applied, iodized oil for iodine deficiency disease (IDD) prevention and treatment began in 1959, mainly by Clarke, McCullagh, Buttfield And Hetzel in wards in Papua New Guinea; used in South America and Africa since 1966. Zhang Changying Beijing Medical University in 1956 with homemade iodized soybean oil to control experimental goiter in rats; 1957 Fang Xin for the prevention and treatment of toxins in the Dabie Mountains; in 1978 in China iodine deficiency disorders began a wide range of Lipiodol prevention and control work. At present, there are mainly two manufacturers of iodized oil for preventing IDD in the world, one is Guerbet in France and the other is No.4 Pharmaceutical Factory in Wuhan. It is learned that Indonesia will also build a lipiodol plant.