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凋亡是人类子宫内膜分泌期的重要特征,细胞对凋亡的敏感性由细胞内多种促凋亡与抗凋亡分子之间的比例所决定。目前在哺乳类动物中至少已发现10个细胞基因,它们编码蛋白质的氨基酸序列与BCL-2有明显的同源性,根据它们的功能可分为两大类,一类是抑制凋亡的,如BCL-2,BCL-Xlong,BCL-W和MCL-1;另一类是促进凋亡的,如BAX,BCL-Xshort,BAK和BAD。BCL-2家族成员之间通过同源二聚体和异二聚体的联合而相互作用。 已发现子宫内膜增生期以BCL-2表达为主,而分泌期则以BAX表达为主,因此
Apoptosis is an important feature of the secretory phase of human endometrium. The sensitivity of cells to apoptosis is determined by the ratio of various pro-apoptotic and anti-apoptotic molecules in the cell. At present, at least 10 cell genes have been found in mammals. The amino acid sequences of the encoded proteins have obvious homology with BCL-2. According to their function, they can be divided into two categories, one is apoptosis-inhibiting, Such as BCL-2, BCL-Xlong, BCL-W and MCL-1; the other is apoptosis-promoting, such as BAX, BCL-Xshort, BAK and BAD. The members of the BCL-2 family interact with each other by a combination of homodimers and heterodimers. It has been found that the endometrial hyperplasia of BCL-2 expression-based, while the secretion of BAX expression is the main, so