FOXC2属翼状螺旋／叉头转录因子家族,在脂肪组织及骨骼肌中均有表达。FOXC2在能量代谢中发挥重要调节作用。研究发现,FOXC2高表达可以诱导棕色脂肪分化,提高胰岛素敏感性, 从而预防肥胖及胰岛素抵抗的发生。最常见的FOXC2基因变异(C-512T)位于5’端非翻译区,该变异可导致体重指数及甘油三酯水平升高,而胰岛素敏感性及基础葡萄糖代谢率降低。 FOXC2 is a family of wing-like helix / forkhead transcription factors that are expressed both in adipose tissue and in skeletal muscle. FOXC2 plays an important regulatory role in energy metabolism. The study found that FOXC2 overexpression can induce brown fat differentiation, improve insulin sensitivity, thus preventing the occurrence of obesity and insulin resistance. The most common FOXC2 gene mutation (C-512T) is located in the 5 ’untranslated region, which can lead to an increase in body mass index and triglyceride levels, with a decrease in insulin sensitivity and basal glucose metabolism.