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大鼠肌注[~3H]十一酸睾丸素油剂,血浆放射峰在药后2d 出现,32d和60d 的血浆放射性分别为峰值的13.3%及9.9%,放射性的分布以肝、肾、脂肪为高,次为提肛肌、附睾、睾丸、前列腺与储精囊。药后60d,肌注部位残留放射性为给药量的19.9%;尿和粪中放射性累积排泄量分别为给药量的41.4%和9.3%。算得 t_((1/2)ka)=6.9d;t_((1/2)α)=6.9d;t_((1/2)β)=15.4d。
The intramuscular injection of [~ 3H] testosterone undecanoate oil and plasma radioactive peak appeared 2 days after treatment. The plasma radioactivity was 13.3% and 9.9% respectively at 32d and 60d. The distribution of radioactivity in liver, kidney and fat was High, second to mention levator ani, epididymis, testis, prostate and seminal vesicle. At 60 days after drug administration, the remaining radioactivity in the intramuscular injection site was 19.9% of the dose; the cumulative cumulative excretion of radioactivity in urine and feces was 41.4% and 9.3% respectively. Calculated t_ ((1/2) ka) = 6.9d; t_ ((1/2) α) = 6.9d; t_ ((1/2) β) = 15.4d.