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目的 探讨肿瘤坏死因子（ＴＮＦ） 与急性脑血管病的关系。方法 测定５０ 例急性脑血管病患者血清ＴＮＦ 浓度，同时以３０ 名健康献血员及门诊体检者为对照组，结果以ｔ 检验作统计学分析。结果 各组脑血管病患者血清ＴＮＦ水平均较对照组（０ ．７４ ±０ ．１５ ｎｇ／ｍｌ） 显著升高（ Ｐ＜ ０００１） ，且与病情程度明显相关。结论 揭示ＴＮＦ参与急性脑血管病的病理生理过程，ＴＮＦ动态观察，可能是判断预后的重要因素。
Objective To investigate the relationship between tumor necrosis factor (TNF) and acute cerebrovascular disease. Methods Serum TNF concentrations were measured in 50 patients with acute cerebrovascular disease. At the same time, 30 healthy blood donors and outpatients were used as control group. The results were analyzed by t test. Results The levels of serum TNF in patients with cerebrovascular disease in each group were significantly higher than those in the control group (0.74 ± 0.15 ng / ml) (P <0001), and were significantly correlated with the severity of the disease. Conclusions TNF is involved in the pathophysiological process of acute cerebrovascular disease. The dynamic observation of TNF may be an important factor in prognosis.