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为探讨氧自出基（ＯＦＲ）在流行性出血热（ＥＨＦ）发病机理中的作用，对５７例流行性出血热患者进行了血清超氧化物歧化酶（ＳＯＤ）和丙二醛（ＭＤＡ）含量的检测。结果显示，血清超氧化物歧化酶和丙二醛从发热期开始各有不同程度的降低与升高，低血压休克期及少尿期变化最显著，三用与正常对照组相比均有显著性差异（Ｐ＜０．０１）．另外，在同一病期中，病情越重，超氧化物歧化酶和丙二醛的变化也越明显。尤其在少尿期，超氧化物歧化酶和丙二醛的变化与少尿持续时间分别呈一定的负相关和正相关。在多尿期及恢复期有恢复的趋势。这提示，在流行性出血热发病过程中，氧自由基是导致机体免疫功能紊乱和病理损伤的重要因素，因此，在临床上检测血清超氧化物歧化酶和丙二醛可作为判定病情轻重及预后的重要指标。
To investigate the role of OFR in the pathogenesis of epidemic hemorrhagic fever (EHF), serum levels of superoxide dismutase (SOD) and malondialdehyde (MDA) were measured in 57 patients with epidemic hemorrhagic fever. The test. The results showed that serum superoxide dismutase and malondialdehyde decreased and increased in varying degrees from the onset of fever, and the changes of hypotension and oliguria were the most significant. The three groups were significantly higher than those of the normal control group Sex differences (P <0.01). In addition, in the same period, the more serious the disease, the more obvious changes of superoxide dismutase and malondialdehyde. Especially in the oliguria period, the changes of superoxide dismutase and malondialdehyde showed a negative correlation with the duration of oliguria. In polyuria and recovery have a recovery trend. This suggests that during the pathogenesis of epidemic hemorrhagic fever, oxygen free radicals are important factors leading to immune dysfunction and pathological damage, therefore, the clinical detection of serum superoxide dismutase and malondialdehyde can be used to determine the severity and Important prognostic indicators.