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目的:探讨2型糖尿病患者踝臂指数(ABI)与尿微量白蛋白/肌酐比值(UACR)的相关性。方法:将100名2型糖尿病患者分为ABI降低组(ABI<1.0)与ABI正常组(1.0≤ABI≤1.3),比较两组患者性别、年龄、病程、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等指标的差异,探讨尿微量白蛋白(UMA)、UACR与ABI异常的相关性。结果:共入选100例患者,其中男62例,女38例,ABI正常组75例,ABI异常组25例,两组的FBG、TC、TG、LDL-C、HDL-C、Hb Alc水平差异均无统计学意义;异常组的BUN、SCr、ACR及24h尿微量蛋白水平均显著高于ABI正常组人群,差异有统计学意义(P<0.05)。多元逐步回归分析结果显示,ACR、24 h尿微量蛋白显著影响ABI指标。结论:2型糖尿病患者踝臂指数与UACR水平密切相关。踝臂指数测定客观、简便,重复性好,无创伤,不但可以用来评估糖尿病患者的外周血管功能状态,还可以评估尿微量白蛋白/肌酐水平,对早期发现糖尿病肾病有一定价值。
Objective: To investigate the relationship between ankle brachial index (ABI) and urinary albumin / creatinine ratio (UACR) in type 2 diabetic patients. Methods: One hundred patients with type 2 diabetes were divided into ABI reduction group (ABI <1.0) and ABI normal group (1.0≤ABI≤1.3). The gender, age, course of disease, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were measured to investigate the correlation between urinary microalbuminuria (UMA) and UACR and ABI abnormalities. Results: A total of 100 patients were selected, including 62 males and 38 females, 75 normal ABI patients and 25 normal ABI patients. There were significant differences in FBG, TC, TG, LDL-C, HDL-C and Hb Alc between the two groups (P <0.05). The levels of BUN, SCr, ACR and 24h urinary protein in abnormal group were significantly higher than those in normal ABI group (P <0.05). Multivariate stepwise regression analysis showed that ACR and 24-hour urinary microalbumin significantly influenced ABI. Conclusion: The ankle-brachial index of type 2 diabetes is closely related to the level of UACR. Ankle-brachial index is objective, simple, reproducible and noninvasive. It can not only evaluate the peripheral vascular function of diabetic patients, but also evaluate the level of urinary albumin / creatinine, which is valuable for the early detection of diabetic nephropathy.