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1962—1972年间,用颈外动脉插管注入氟脲嘧啶治疗口腔癌30例,皆为鳞状细胞癌,多数(25例)为晚期,13例(43.3％)伴颈淋巴结转移。30例均经颞浅动脉或枕动脉插管,分次注入氟脲嘧啶,次量500—1,000毫克,1次/日,多数(22例)总量5,100～9,000毫克,除总量2,500毫克1例无效外,29例皆见肿瘤缩小,其中缩小1/2以上11例,消失9例,以腭癌7例效果较好,皆缩小1/2以上,包括单独化疗后肿瘤消失1例,现已健在13年。30例中除单独动脉化疗外,尚进行其他治疗25例,5年健在率为30％(9/30)。文中介绍枕动脉插管的操作方法,并对本疗法的几项重要环节进行讨论。
Between 1962 and 1972, 30 cases of oral cancer were treated with fluorouracil infusion into the external carotid artery, all of which were squamous cell carcinomas. The majority (25 cases) were advanced and 13 cases (43.3%) had cervical lymph node metastasis. All 30 cases were intubated through the superficial temporal artery or occipital artery and injected with fluorouracil in divided doses of 500-1,000 mg once daily. The majority (22 cases) totaled 5,100-9,000 mg, with a total of 2,500 mg 1 Invalid cases, 29 cases were seen tumor shrinkage, which reduced 1/2 11 cases, disappeared in 9 cases, 7 cases of carcinoid tumors were better, are reduced by 1/2 or more, including chemotherapy after chemotherapy disappeared in 1 case, now Has been alive for 13 years. Among the 30 patients, 25 were treated with other treatments except arterial chemotherapy alone. The 5-year survival rate was 30% (9/30). This article describes the operation method of occipital arterial cannulation and discusses several important aspects of this therapy.