目的为了探讨抗焦虑药物治疗焦虑症状的分子作用机制。方法建立大鼠束缚应激模型,观察抗焦虑药物帕罗西汀用药组大鼠的旷场行为和下丘脑cfos的表达。结果与正常对照组比较,应激大鼠在旷场中的穿行格数和直立次数明显增加,下丘脑室旁核cfos表达显著增加,而帕罗西汀用药组能减少大鼠在旷场中的活动和下丘脑室旁核cfos表达。结论帕罗西汀对束缚应激大鼠脑保护作用可能与下调cfos基因表达有关。 Objective To explore the molecular mechanism of anti-anxiety treatment of anxiety symptoms. Methods The rat restraint stress model was established to observe the open field behavior and the expression of cfos in the hypothalamus of paroxetine-treated rats. Results Compared with the normal control group, the number of transit cells and the upright number of the stressed rats increased significantly in the open field, and the cfos expression in the paraventricular nucleus of the hypothalamus significantly increased, while the paroxetine treatment group decreased the rats’ activity in the open field And cfos expression in hypothalamic paraventricular nucleus. CONCLUSION Paroxetine may play a protective role in restraint stress-induced stress in rats, which may be related to down-regulation cfos gene expression.