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应用ＡＢＣ免疫组化法对９３例膀胱移行细胞癌组织中的原癌基因ｃ－ｅｒｂＢ－２和抑癌基因Ｐ５３的表达及共同表达的意义进行了研究。结果显示：ｃ－ｅｒｂＢ－２和Ｐ５３的阳性表达率分别为２６％和４８％，二者共同表达率为２１．５％，共同表达与肿瘤的病理分级（Ｐ＜０．０５），临床分期（Ｐ＜０．０１），复发（Ｐ＜０．０５）关系极为密切。提示ｃ－ｅｒｂＢ－２和Ｐ５３与膀胱移行细胞癌的发生、发展、尤其与肿瘤的侵袭性密切相关，并且二者可能有协调作用。同时检测两者的表达情况，可为临床判断膀胱移行细胞癌预后提供可靠的依据。
The expression of c-erbB-2 and tumor suppressor gene P53 in 93 cases of transitional cell carcinoma of the bladder were studied by ABC immunohistochemistry. The results showed that the positive rates of c-erbB-2 and P53 were 26% and 48%, respectively. The positive rate of c-erbB-2 and P53 was 21.5%, which was correlated with the pathological grade of tumor (P <0.05) (P <0.01) and relapse (P <0.05). Prompted c-erbB-2 and P53 and bladder transitional cell carcinoma of the occurrence and development, especially with the invasiveness of the tumor is closely related, and the two may have a coordinating role. Simultaneous detection of the expression of both, can provide a reliable basis for the clinical diagnosis of bladder transitional cell carcinoma prognosis.