α-干扰素(IFNα)治疗可使40%慢性丙型肝炎病毒(HCV)感染者的血清ALT活性降至正常,但停药后,有效者中至少半数复发。虽然有研究表明IFNα治疗后血清ALT降至正常者的血清HCV RNA可能阴转,但生化证据完全或持续有效者是否伴有持续性HCV消失尚不明了。 本研究中15例慢性HCV感染者随机接受IFNα治疗。根据对IFNα的生化疗效分为3组;(1)无效组(5例),治疗期间与 IFN-alpha treatment reduced serum ALT activity in 40% of people infected with chronic hepatitis C virus (HCV), but relapsed after discontinuation of at least 50% of those who were active. Although studies have shown that serum HCV RNA may be negatively converted to normal serum ALT after IFNα treatment, it is unclear whether complete or persistent biochemical evidence is associated with persistent HCV disappearance. Fifteen patients with chronic HCV infection in our study were randomized to receive IFNα. According to the biochemical efficacy of IFNα divided into 3 groups; (1) ineffective group (5 cases), the treatment period