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目的通过检测新生儿高胆红素血症患儿血清神经元特异性烯醇化酶(NSE)的变化,探讨NSE诊断新生儿胆红素脑病的意义。方法 36名健康新生儿和96名本院新生儿室收治的高胆红素血症患者静脉采血利用化学发光法检测血清NSE水平,同时做脑干听觉诱发电位(BAEP)检测。结果 NSE异常患儿BAEP异常率在观察组与轻度升高、中度升高与重度升高各组间比较p<0.05,差异具有统计学意义。在轻度升高组与中度升高组比较p>0.05,差异无统计学意义。结论 NSE检测较BAEP测定能更早期诊断新生儿胆红素脑病。
Objective To detect the changes of serum neuron-specific enolase (NSE) in neonates with hyperbilirubinemia and to explore the significance of NSE in the diagnosis of neonatal bilirubin encephalopathy. Methods Thirty-six healthy neonates and 96 neonates with hyperbilirubinemia were enrolled in this study. Serum NSE levels were measured by chemiluminescence assay and brainstem auditory evoked potentials (BAEP) were measured at the same time. Results The abnormal rate of BAEP in children with abnormal NSE was significantly lower in the observation group than in the mild, moderate and severe groups (p <0.05). The difference was statistically significant. In mild increase group and moderate increase group compare p> 0.05, the difference was not statistically significant. Conclusion NSE can diagnose neonatal bilirubin encephalopathy earlier than BAEP.